The Maritime Domain Awareness Center– A Human-Centered Design Approach

This paper contends that Maritime Domain Awareness Center (MDAC) design should be a holistic approach integrating established knowledge about human factors, decision making, cognitive tasks, complexity science, and human information interaction. The design effort should not be primarily a technology effort that focuses on computer screens, information feeds, display technologies, or user interfaces. The existence of a room with access to vast amounts of information and wall-to-wall video screens of ships, aircraft, weather data, and other regional information does not necessarily correlate to possessing situation awareness. Fundamental principles of human-centered information design should guide MDAC design and technology selection, and it is imperative that they be addressed early in system development. The design approach should address the reason and purpose for a given MDAC. Subsequent design efforts should address ergonomic interaction with information – the relationship of the brain to the information ecosystem provided by the MDAC, and the cognitive science of situation awareness and decision making. This understanding will guide technology functionality. The system user and decision maker should be the focus of the information design specifications, and this user population must participate and influence the information design. Accordingly, this paper provides a “design gestalt” by which to approach the design and development of an MDAC

Smooth muscle cell phenotypic switching in atherosclerosis

Smooth muscle cells (SMCs) possess remarkable phenotypic plasticity that allows rapid adaptation to fluctuating environmental cues, including during development and progression of vascular diseases such as atherosclerosis. Although much is known regarding factors and mechanisms that control SMC phenotypic plasticity in cultured cells, our knowledge of the mechanisms controlling SMC phenotypic switching in vivo is far from complete. Indeed, the lack of definitive SMC lineage-tracing studies in the context of atherosclerosis, and difficulties in identifying phenotypically modulated SMCs within lesions that have down-regulated typical SMC marker genes, and/or activated expression of markers of alternative cell types including macrophages, raise major questions regarding the contributions of SMCs at all stages of atherogenesis. The goal of this review is to rigorously evaluate the current state of our knowledge regarding possible phenotypes exhibited by SMCs within atherosclerotic lesions and the factors and mechanisms that may control these phenotypic transition

Thickness dependent interlayer transport in vertical MoS2 Josephson junctions

We report on observations of thickness dependent Josephson coupling and multiple Andreev reflections (MAR) in vertically stacked molybdenum disulfide (MoS2) - molybdenum rhenium (MoRe) Josephson junctions. MoRe, a chemically inert superconductor, allows for oxide free fabrication of high transparency vertical MoS2 devices. Single and bilayer MoS2 junctions display relatively large critical currents (up to 2.5 uA) and the appearance of sub-gap structure given by MAR. In three and four layer thick devices we observe orders of magnitude lower critical currents (sub-nA) and reduced quasiparticle gaps due to proximitized MoS2 layers in contact with MoRe. We anticipate that this device architecture could be easily extended to other 2D materials.Comment: 18 pages, 6 figures including Supporting Informatio

Sequence patches on MAPK surfaces define protein-protein interactions

Redesigning ‘surface patches’ on a mitogen-activated protein kinase can change its interactions with other proteins

Approaching ultra-strong coupling in Transmon circuit-QED using a high-impedance resonator

In this experiment, we couple a superconducting Transmon qubit to a high-impedance $645\ \Omega$ microwave resonator. Doing so leads to a large qubit-resonator coupling rate $g$, measured through a large vacuum Rabi splitting of $2g\simeq 910$ MHz. The coupling is a significant fraction of the qubit and resonator oscillation frequencies $\omega$, placing our system close to the ultra-strong coupling regime ($\bar{g}=g/\omega=0.071$ on resonance). Combining this setup with a vacuum-gap Transmon architecture shows the potential of reaching deep into the ultra-strong coupling $\bar{g} \sim 0.45$ with Transmon qubits

The Influence of Low-Energy Algorithms on Steganography

Recent advances in pseudorandom archetypes and client- server methodologies have introduced a domain for e-business. Given the current status of concurrent configurations, theorists daringly desire the evaluation of e-business, demonstrates the private importance of steganography. Our focus in our research is not on whether lambda calculus and 802.11b are often incompatible, but rather on exploring a novel methodology for the refinement of forward-error correction (Gerocomy)